Publikationer

Publikationer

rA1M-035, a physicochemically improved human recombinant A1M, has therapeutic effects in rhabdomyolysis-induced acute kidney injury. Åkerström B, Rosenlöf L, Hägerwall A, Rutardóttir S, Ahlstedt J, Johansson ME, Erlandsson L, Allhorn M, Gram M.
Antioxid Redox Signal. 2019 Feb 1;30(4):489-504.

Structural and biochemical characterization of two heme binding sites on A1M using site-directed mutagenesis and molecular simulation. Rutardóttir S, Karnaukhova E, Nantasenamat C, Songtawee N, Prachayasittikul V, Rajabi M, Rosenlöf L, Alayash AI, Åkerström B.
Biochim Biophys Acta. 2016 Jan;1864(1):29-41.

A1M ameliorates preeclampsia-like symptoms in placenta and kidney induced by cell-free fetal hemoglobin in rabbit. Nääv Å, Erlandsson L, Axelsson J, Larsson I, Johansson M, Rosenlöf L, Mörgelin M, Casslén V, Gram M, Åkerström B, Hansson SR.
PLoS One. 2015 May 8;10(5):e0125499.

A1M protects from heme-induced placental and renal damage in a pregnant sheep model of preeclampsia. Rosenlöf L, Casslén V, Axelsson J, Hägerwall A, Gram M, Holmqvist M, Johansson ME, Larsson I, Ley D, Marsal K, Mörgelin M, Rippe B, Rutardóttir S, Shohani B, Åkerström B, Hansson SR.
PLoS One. 2014 Jan 28;9(1):e86353.

A1M, an extravascular tissue cleaning and housekeeping protein. Åkerström B, Gram M.
Free Radic Biol Med. 2014 Sep;74:274-82.

The radical-binding lipocalin A1M binds to a Complex I subunit and protects mitochondrial structure and function. Olsson MG, Rosenlöf L, Kotarsky H, Olofsson T, Leanderson T, Mörgelin M, Fellman V, Åkerström B.
Antioxid Redox Signal. 2013 Jun 1;18(16):2017-28.

The lipocalin A1M protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species. Olsson MG, Olofsson T, Tapper H, Åkerström B.
Free Radic Res. 2008 Aug;42(8):725-36.

The lipocalin A1M has radical scavenging activity. Åkerström B, Maghzal GJ, Winterbourn CC, Kettle AJ.
J Biol Chem. 2007 Oct 26;282(43):31493-503.

Redox properties of the lipocalin A1M: reduction of cytochrome c, hemoglobin, and free iron. Allhorn M, Klapyta A, Åkerström B.
Free Radic Biol Med. 2005 Mar 1;38(5):557-67.

Processing of the lipocalin A1M by hemoglobin induces heme-binding and heme-degradation properties. Allhorn M, Berggård T, Nordberg J, Olsson ML, Åkerström B.
Blood. 2002 Mar 15;99(6):1894-901.

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